Side Effects of Flexeril cyclobenzaprine: Interactions & Warnings

Side Effects of Flexeril cyclobenzaprine: Interactions & Warnings

Addiction Resource is an educational platform for sharing and disseminating information about addiction and substance abuse recovery centers. Addiction Resource is not a healthcare provider, nor does it claim to offer sound medical advice to anyone. Addiction Resource does not favor or support any specific recovery center, nor do we claim to ensure the quality, validity, or effectiveness of any particular treatment center. No one should assume the information provided on Addiction Resource as authoritative and should always defer to the advice and care provided by a medical doctor. As Cyclobenzaprine belongs to the drug class of cyclic antidepressants, it has inherent serotonergic activity.

This page will go over its side effects, drug interactions, and treatment for misuse. Taking this drug with an MAOI or within 14 days of stopping an MAOI could increase your risk of serious side effects. In patients with CNS depression, early intubation is advised because of the potential for abrupt deterioration. Seizures should be controlled with benzodiazepines or, if these are ineffective, other anticonvulsants (e.g. phenobarbital, phenytoin).

  • Eight double-blind controlled clinical studies were performed in 642 patients comparing FLEXERIL 10 mg, diazepam, and placebo.
  • However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist.
  • There are no adequate studies of Flexeril in pregnant women.
  • If a person is prescribed cyclobenzaprine, they should make sure their health care provider knows all medications they are taking (including over-the-counter medications), as well as if they drink alcohol or use other drugs.
  • Do not increase your dose or use this drug more often or for longer than prescribed.

This enables the provider to evaluate for any potential interactions and helps them keep the patient safe. Even if it feels like the effects of cyclobenzaprine have worn off, the drug may not be completely eliminated from the body yet and could cause serious interactions with other substances. Some medicines can interact with cyclobenzaprine and cause a serious condition called serotonin syndrome. Ask your doctor before making any changes in how or when you take your medications. According to the Food and Drug Administration (FDA), patients should avoid use of monoamine oxidase (MAO) inhibitors within 14 days of cyclobenzaprine use. Seizures and even death have occurred in patients who have cyclobenzaprine or other structurally similar tricyclic antidepressants with MAO inhibitor drugs.

Patient Handout

Tell your care team if your symptoms do not start to get better or if they get worse. Ask your pharmacist any questions you have about refilling your prescription. Avoid driving or hazardous activity until you know how this medicine will affect you.

Although not all of these side effects may occur, if they do occur they may need medical attention. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections. The amount of medicine that you take depends on the strength of the medicine.

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There is no evidence to suggest that the drug causes any issues for pregnant mothers (according to studies done on mice, rats and rabbits), but there have yet to be any adequate and well-controlled studies in pregnant women. As a result, the FDA cautions use during pregnancy only if clearly needed. For nursing mothers, it is unknown if cyclobenzaprine is excreted in human milk. However, because it is closely related to tricyclic antidepressants, which are excreted in human milk, the FDA cautions against breastfeeding if using cyclobenzaprine. It is usually used in conjunction with rest, physical therapy and other measures.

The overall incidence of adverse reactions among patients in the surveillance program was less than the incidence in the controlled clinical studies. By residing in a facility full-time, patients can focus exclusively on their recovery without the added pressures and stressors of the outside world. The FDA recommends cautious use of cyclobenzaprine in patients with a history of urinary retention and glaucoma or other eye problems.

Cyclobenzaprine (Flexeril): Dosage & Side Effects

This medication should only be used short-term (for 3 weeks or less) unless directed by your doctor. Ask your healthcare professional how you should dispose of any medicine you do not use. The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

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Taking more may result in adverse Flexeril side effects or overdose. Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects.

Overall rating for Cyclobenzaprine (Flexeril)

Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, flexeril.live procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication.

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